1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: -78 - 20 °C 2.1: n-butyllithium / hexane; diethyl ether / 1 h / 0 - 20 °C / |Inert atmosphere 2.2: 1 h / 20 °C 3.1: hydrogenchloride; water / methanol / 1 h / 50 °C View Scheme

1: 1) n-BuLi / 1) THF, -78 dec C, 30 min, 2) to RT 3: 77 percent / 4N HCl / tetrahydrofuran / 3 h / Heating 4: 79 percent / 2,6-lutidine / CH2Cl2 / 1 h / -30 - 0 °C 5: 64 percent / LiCl, DBU / bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 3 h / 120 °C View Scheme