(2R,3s,4r,5r)-2-(羟基甲基)-5-(6-甲基-9h-嘌呤-9-基)四氢呋喃-3,4-二醇合成路线 （共 15 条）
反应条件
1: 88 percent / phenyltrimethylammonium perbromide / methanol / 0.17 h 2: 50 percent / K2CO3 / acetone / 24 h / Ambient temperature 3: 57 percent / NaI / acetone / 4 h / Ambient temperature 4: 88 percent / NaBH4 / methanol / 0.25 h / Ambient temperature 5: 75 percent / satd. NH3/MeOH / 2 h / Ambient temperature View Scheme
参考文献
Shimazaki, Masami; Nakamura, Hikaru; Iitaka, Yoichi; Ohno, Masaji
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3104 - 3112
反应条件
1: 50 percent / K2CO3 / acetone / 24 h / Ambient temperature 2: 57 percent / NaI / acetone / 4 h / Ambient temperature 3: 88 percent / NaBH4 / methanol / 0.25 h / Ambient temperature 4: 75 percent / satd. NH3/MeOH / 2 h / Ambient temperature View Scheme
参考文献
Shimazaki, Masami; Nakamura, Hikaru; Iitaka, Yoichi; Ohno, Masaji
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3104 - 3112
反应条件
1: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 20 h / 60 °C / Inert atmosphere 2: methylamine View Scheme
参考文献
Ellermann, Manuel; Paulini, Ralph; Jakob-Roetne, Roland; Lerner, Christian; Borroni, Edilio; Roth, Doris; Ehler, Andreas; Schweizer, W. Bernd; Schlatter, Daniel; Rudolph, Markus G.; Diederich, Francois
Chemistry - A European Journal, 2011 , vol. 17, # 23 p. 6369 - 6381
反应条件
trimethylsilyl trifluoromethanesulfonate
参考文献
Loennberg, Harri; Kaeppi, Rainer; Lehikoinen, Pertti; Oivanen, Mikko
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 1 p. 34 - 40
反应条件
E. coli purine nucleoside phosphorylase Substitution; Enzyme kinetics;
参考文献
Secrist III, John A.
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 745 - 757
