5,5,5-三氟-4-羟基-4-苯基戊烷-2-酮合成路线 （共 5 条）
反应条件
1: 2,2,2-Trifluoro-1-phenyl-ethanone With N-methyl-2-(methylamino)ethylamine in hexane T=20°C; 0.166667 h; Inert atmosphere; 2: With diethylzinc in hexane T=20°C; 0.166667 h; Inert atmosphere; 3: acetone in hexane T=20°C; 20 h; Inert atmosphere;
参考文献
Sasaki, Shigeru; Kikuchi, Kasumi; Yamauchi, Takayasu; Higashiyama, Kimio
Synlett, 2011 , # 10 art. no. U02211ST, p. 1431 - 1434
反应条件
lithium hydride in pentane 1 h; Heating;
参考文献
Sosnovskikh, V. Ya.; Ovsyannikov, I. S.; Aleksandrova, I. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 3.1 p. 420 - 426
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 3 p. 518 - 526
反应条件
iso-PrOLi in toluene T=20 - 80°C; 6 h;
参考文献
Sokeirik, Yasser S.; Sato, Kazuyuki; Omote, Masaaki; Ando, Akira; Kumadaki, Itsumaro
Journal of Fluorine Chemistry, 2006 , vol. 127, # 1 p. 150 - 152
反应条件
1: 92 percent / diethyl ether / 1 h / 20 °C 2: 56 percent / aq. HCl / ethanol / 1 h / Heating View Scheme
参考文献
Barten, Jan Alexander; Funabiki, Kazumasa; Roeschenthaler, Gerd-Volker
Journal of Fluorine Chemistry, 2002 , vol. 113, # 1 p. 105 - 109
反应条件
hydroxide in water T=25°C; var. conc. of OH-; Rate constantEquilibrium constant;
参考文献
Guthrie, J. Peter; Barker, Jonathan A.
Journal of the American Chemical Society, 1998 , vol. 120, # 27 p. 6698 - 6703
