3-(2-羟基乙基)-2-吡啶甲腈合成路线 （共 1 条）
反应条件
1: CH2Cl2
2: 70 percent / KH / CH2Cl2 / Ambient temperature
3: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C
4: imidazole
5: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C
6: MsCl, Et3N
7: CSA / ethanol
8: Dess-Martin periodinane (DMP)
9: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C
10: 98 percent / methanol
11: Dess-Martin periodinane (DMP)
12: NaClO2, NaH2PO4 / various solvent(s)
14: 1) HCO2H, 2) H2O / 2) 140 deg C
15: 3 N KOH / 120 °C
View Scheme
参考文献
Horikawa, Manabu; Hashimoto, Kimiko; Shirahama, Haruhisa
Tetrahedron Letters, 1993 , vol. 34, # 2 p. 331 - 334
