2-(1-氧代-3-吡啶基)乙醇合成路线 （共 1 条）
反应条件
1: Me2NCOCl / CH2Cl2
2: methanol
3: CH2Cl2
4: 70 percent / KH / CH2Cl2 / Ambient temperature
5: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C
6: imidazole
7: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C
8: MsCl, Et3N
9: CSA / ethanol
10: Dess-Martin periodinane (DMP)
11: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C
12: 98 percent / methanol
13: Dess-Martin periodinane (DMP)
14: NaClO2, NaH2PO4 / various solvent(s)
16: 1) HCO2H, 2) H2O / 2) 140 deg C
17: 3 N KOH / 120 °C
View Scheme
参考文献
Horikawa, Manabu; Hashimoto, Kimiko; Shirahama, Haruhisa
Tetrahedron Letters, 1993 , vol. 34, # 2 p. 331 - 334
