1: 91 percent / ethyl acetate; H2O / 24 h / 50 °C 2: 57 percent 3: 62 percent / 4-methylmorpholine; 2-chloro-4,6-dimethoxy-1,3,5-triazine / 20 °C View Scheme

1: hydrogen; 5 palladium on charcoal / dichloromethane / 3.5 h / 3345.86 Torr / |Inert atmosphere; |Autoclave; |Large scale 2: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / -10 - 20 °C / pH 9.5 / |Large scale 3: DBBA; hydrogen bromide; acetic acid / dichloromethane / 25 °C / |Large scale 4: sodium acetate / water; acetonitrile / 3 h / 40 °C / |Large scale 5: sodium hydroxide / water / 1.5 h / 40 °C / |Large scale 6: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methylmorpholine N-oxide / N,N-dimethyl-formamide / 1.5 h / 25 °C / |Large scale View Scheme

1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / -10 - 20 °C / pH 9.5 / |Large scale 2: DBBA; hydrogen bromide; acetic acid / dichloromethane / 25 °C / |Large scale 3: sodium acetate / water; acetonitrile / 3 h / 40 °C / |Large scale 4: sodium hydroxide / water / 1.5 h / 40 °C / |Large scale 5: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methylmorpholine N-oxide / N,N-dimethyl-formamide / 1.5 h / 25 °C / |Large scale View Scheme

1: 5,5-dibromomeldrum's acid; hydrogenchloride / diethyl ether / 24 h / 20 °C 2: sodium acetate / water; methanol / 3 h / 45 °C 3: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere 4: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 6 h / 20 °C View Scheme

1: sodium acetate / water; methanol / 3 h / 45 °C 2: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere 3: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 6 h / 20 °C View Scheme

1: sodium hydroxide / methanol / 24 h / 40 - 50 °C / |Inert atmosphere 2: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methyl-morpholine / N,N-dimethyl-formamide / 6 h / 20 °C View Scheme

T=20 - 25°C; 1 h;

2: 1 h / 20 - 25 °C View Scheme

in ethanol 3 h; RefluxLarge scale;