2-溴-4-氯-6-甲基苯胺合成路线 （共 10 条）
反应条件
1: With SPB; ammonium heptamolybdate; acetic acid; potassium bromide T=0 - 20°C; 2.5 h; 2: With sodium hydrogencarbonate in water
参考文献
Bristol-Myers Squibb Company
Patent: US2009/18132 A1, 2009 ;
Location in patent: Page/Page column 56 ;
US 20090018132 A1
反应条件
N-bromosuccinmide in acetonitrile T=0°C; 1.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/51533 A2, 2008 ;
Location in patent: Page/Page column 93 ;
WO 2008/051533 A2
反应条件
hydrogenchloride; tin
参考文献
Cohen; Murray
Journal of the Chemical Society, 1915 , vol. 107, p. 849
反应条件
1: concentrated hydrochloric acid; sodium chlorate / nachfolgende Verseifung 3: fuming nitric acid / <5 4: tin; hydrochloric acid View Scheme
参考文献
Cohen; Murray
Journal of the Chemical Society, 1915 , vol. 107, p. 849
反应条件
2: fuming nitric acid / <5 3: tin; hydrochloric acid View Scheme
参考文献
Cohen; Murray
Journal of the Chemical Society, 1915 , vol. 107, p. 849
反应条件
1: fuming nitric acid / <5 2: tin; hydrochloric acid View Scheme
参考文献
Cohen; Murray
Journal of the Chemical Society, 1915 , vol. 107, p. 849
参考文献
Cohen; Murray
Journal of the Chemical Society, 1915 , vol. 107, p. 849
参考文献
Cohen; Murray
Journal of the Chemical Society, 1915 , vol. 107, p. 849
反应条件
palladium diacetate; 1,4-di(diphenylphosphino)-butane in ethylene glycol T=25 - 110°C; P=2842.59 Torr; Inert atmosphereSealed tube;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY; KRISTJANSDOTTIR, Sigridur, Soley; SHAPIRO, Rafael; OBERHOLZER, Matthew, Richard
Patent: WO2012/103436 A1, 2012 ;
Location in patent: Page/Page column 26-28 ;
反应条件
copper(l) iodide in methanol
T=100°C; 2 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/51533 A2, 2008 ;
Location in patent: Page/Page column 93-94 ;
WO 2008/051533 A2
