3-氨基-4-(环丙基氨基)吡啶合成路线 （共 7 条）
反应条件
palladium on activated charcoal; hydrogen in ethanol; water P=2585.81 Torr; 4 h; Inert atmosphere;
参考文献
Provencal, David P.; Gesenberg, Kirsten D.; Wang, Hua; Escobar, Carlos; Wong, Henry; Brown, Matthew A.; Staab, Andrew J.; Pendri, Yadagiri R.
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 903 - 908
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / Reflux 2: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C / 2585.81 Torr View Scheme
参考文献
WO2012/80447 A1, ;
WO2012/80450 A1, ;
WO2012/80449 A1, ;
WO 2012/080449 A1
WO2012/80451 A1, ;
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 10 h / Reflux 2: hydrogen / palladium 10 on activated carbon / ethanol; water / 16 h / 20 °C / 2585.81 Torr View Scheme
反应条件
1.1: sulfuric acid; potassium nitrate / 1 h / 0 - 100 °C / |Inert atmosphere 2.1: trichlorophosphate / 1,2-dichloro-ethane / 4 h / 80 - 85 °C / |Inert atmosphere 2.2: 1 h / 0 - 65 °C / |Inert atmosphere 3.1: 100 °C / |Sealed tube; |Inert atmosphere 4.1: palladium on activated charcoal; hydrogen / ethanol; water / 4 h / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 903 - 908
反应条件
1.1: trichlorophosphate / 1,2-dichloro-ethane / 4 h / 80 - 85 °C / |Inert atmosphere 1.2: 1 h / 0 - 65 °C / |Inert atmosphere 2.1: 100 °C / |Sealed tube; |Inert atmosphere 3.1: palladium on activated charcoal; hydrogen / ethanol; water / 4 h / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 903 - 908
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 3 h / 0 °C / |Sealed tube; |Inert atmosphere 2: palladium on activated charcoal; hydrogen / ethanol; water / 4 h / 2585.81 Torr / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 903 - 908
反应条件
in acetonitrile T=0 - 20°C; 16 h;
参考文献
WO2012/80446 A1, ;
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