5’-O-(4,4-二甲氧基三苯甲基)-2’-脱氧-2’-氟尿苷-3’-(2-氰基乙基-N,N-二异丙基)亚磷酰胺合成路线 (共 4 条)
反应条件
N,N-diisopropylamine tetrazolide in dichloromethane T=23°C; 8 h;
参考文献
Kawasaki; Casper; Freier; Lesnik; Zounes; Cummins; Gonzalez; Cook
Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 831 - 841
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane 1.) 0 deg C, 5 min; 2.) RT, 2 h;
参考文献
Reif, Bernd; Wittmann, Valentin; Schwalbe, Harald; Griesinger, Christian; Woerner, Karlheinz; Jahn-Hofmann, Kerstin; Engels, Joachim W.; Bermel, Wolfgang
Helvetica Chimica Acta, 1997 , vol. 80, # 6 p. 1952 - 1971
反应条件
1: 97 percent / Et3N / pyridine / 1.5 h 2: 84 percent / (i-Pr)2EtN / CH2Cl2 / 1.) 0 deg C, 5 min; 2.) RT, 2 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 80, # 6 p. 1952 - 1971
反应条件
1: 97 percent / Et3N / pyridine / 1.5 h 2: 84 percent / (i-Pr)2EtN / CH2Cl2 / 1.) 0 deg C, 5 min; 2.) RT, 2 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 80, # 6 p. 1952 - 1971