反应条件
1: 95 percent / Et3N / CH2Cl2 / 2.5 h / 0 °C 2: 76 percent / B2H6*THF / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) r.t., 1 h 3: 87 percent / SO3*pyridine, Et3N / dimethylsulfoxide / 2.5 h / 7 - 8 °C 4: 1.) i-Pr2N, n-BuLi, MgBr2*Et2O / 1.) THF, hexane, -78 deg C, 30 min; -78 deg C to r.t., 2 h; -78 deg C, 1 h, 2.) THF, -95 deg C, 2 h 5: 62 percent / BF3*Et2O / CH2Cl2 / 1 h / -78 °C 6: 57 percent / potassium tert-butoxide / tetrahydrofuran / 0.08 h / -20 - -15 °C 7: 94 percent / H2 / 10percent Pd/C / methanol / 12 h / Ambient temperature View Scheme
参考文献
Pettit, George R.; Singh, Sheo Bux; Herald, Delbert L.; Lloyd-Williams, Paul; Kantoci, Darko; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6287 - 6295
