4-氨基-5-氟-1-[(2S,5R)-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮合成路线 （共 12 条）
反应条件
1.1: iodotrimethylsilane; 2,6-lutidine / CH2Cl2
2.1: NaBH4 / ethanol; CH2Cl2
2.2: 51 percent / NH3(g) / methanol
View Scheme
参考文献
Mansour, Tarek S.; Tse, Allan; Charron, Marie; Hooker, Elizabeth U.; Ashman, Clare; et al.
Medicinal Chemistry Research, 1995 , vol. 5, # 6 p. 417 - 425
反应条件
1: N,O-bis(trimethylsilyl)acetamide, TMSOTf / toluene; acetonitrile / 1.) 90 deg C, 2.) 0 deg C
2: Et4NF / tetrahydrofuran
View Scheme
参考文献
Van Draanen; Koszalka
Nucleosides and Nucleotides, 1994 , vol. 13, # 8 p. 1679 - 1693
