(s)-(-)-N-叔丁氧羰基-3-氨基吡咯烷合成路线 （共 12 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=760.051 Torr; 6 h;
参考文献
Vetoquinol SA
Patent: US2009/221565 A1, 2009 ;
Location in patent: Page/Page column 51 ;
US 20090221565 A1
反应条件
1: (S)-3-aminopyrrolidine dihydrochloride With sodium carbonate in methanol 0.75 h; 2: di-tert-butyl dicarbonate in methanol T=0°C; 3 h;
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
反应条件
potassium hydroxide in methanol T=15 - 20°C; pH=11.8 - 12.2; 1 h;
参考文献
EP1460061 A1, ;
Page 5-6 ;
参考文献
EP1460061 A1, ;
Page 6 ;
参考文献
US2007/219240 A1, ;
Page/Page column 23 ;
US 20070219240 A1
反应条件
lithium hydroxide in tetrahydrofuran T=20°C; 18 h;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 18 p. 2933 - 2949
反应条件
in tetrahydrofuran; water
参考文献
US6441017 B1, ;
US 6441017 B1
反应条件
1: TCI; iPr2NEt / CH2Cl2 / 2 h / 20 °C 2: aq. LiOH / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 18 p. 2933 - 2949
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 20 h / 95 °C 3: triphenylphosphine; water / tetrahydrofuran / 5 h / 20 - 50 °C / Cooling with ice View Scheme
