(R)-1-Boc-3-氨基吡咯烷合成路线 （共 13 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=760.051 Torr; 6 h;
参考文献
Vetoquinol SA
Patent: US2009/221565 A1, 2009 ;
Location in patent: Page/Page column 50 ;
US 20090221565 A1
反应条件
hydrogen; palladium dihydroxide in methanol T=20°C; P=3800.26 Torr; 16 h;
参考文献
Davies, Stephen G.; Garner, A. Christopher; Goddard, Euan C.; Kruchinin, Dennis; Roberts, Paul M.; Smith, Andrew D.; Rodriguez-Solla, Humberto; Thomson, James E.; Toms, Steven M.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 12 p. 1961 - 1969
反应条件
ammonia in water T=80 - 90°C; P=3000.3 - 6000.6 Torr; 10 - 19 h; Product distribution / selectivity;
参考文献
Kaneka Corporation
Patent: EP2050735 A1, 2009 ;
Location in patent: Page/Page column 19-20 ;
反应条件
N-ethyl-N,N-diisopropylamine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
US2002/65270 A1, ;
US 20020065270 A1
反应条件
hydrogenchloride in methanol T=0°C;
参考文献
Ashton; Aumann, Kylee M.; Baker, Stephen P.; Schiesser, Carl H.; Scammells, Peter J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6779 - 6784
反应条件
ω-transaminase from Alcaligenes denitrificans; pyridoxal 5'-phosphate; 2-oxo-propionic acid in sodium phosphate buffer T=37°C; pH=8; 7 h; kinetic resolutionEnzymatic reaction; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 6 p. 807 - 812
反应条件
sodium hydroxide; water in toluene Product distribution / selectivity;
参考文献
EP2050735 A1, ;
Page/Page column 20 ;
反应条件
hydrogenchloride in water; ethyl acetate T=0 - 22°C; 1 h;
参考文献
EP2050735 A1, ;
Page/Page column 22 ;
反应条件
sodium borohydride in methanol; hexane; ethyl acetate
参考文献
Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.
Patent: US2005/70549 A1, 2005 ;
反应条件
in methanol; hexane; dichloromethane; ethyl acetate; acetone
参考文献
Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.
Patent: US2005/70549 A1, 2005 ;
