3-甲氨基-1-BOC吡咯烷合成路线 (共 5 条)
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 18 h; 2: With methanol
参考文献
PFIZER LIMITED
Patent: WO2006/64336 A2, 2006 ;
Location in patent: Page/Page column 43-44 ;
反应条件
in tetrahydrofuran T=95°C; 60 h; Sealed tube;
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
Location in patent: Page/Page column 71 ;
反应条件
in dichloromethane T=0°C; 1 h;
参考文献
Zhang, Mingzhu; Tamiya, Junko; Nguyen, Linh; Rowbottom, Martin W.; Dyck, Brian; Vickers, Troy D.; Grey, Jonathan; Schwarz, David A.; Heise, Christopher E.; Haelewyn, Jason; Mistry, Monica S.; Goodfellow, Val S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2535 - 2539
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C 2: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 3: tetrahydrofuran / 60 h / 95 °C / Sealed tube View Scheme
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 2: tetrahydrofuran / 60 h / 95 °C / Sealed tube View Scheme