(3R)-叔丁基二甲硅氧基-5-氧代-6-三苯基膦烯己酸甲酯合成路线 （共 23 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 30°C; Wittig Reaction;
参考文献
US2012/310000 A1, ;
Page/Page column 5 ;
反应条件
potassium carbonate in dichloromethane T=-10 - 10°C; Wittig Reaction;
参考文献
US2012/310000 A1, ;
Page/Page column 10 ;
反应条件
1: Hydrogen (3R)-1-methyl 3-lt;(tert-butyldimethylsilyl)oxygt;pentanedioate With chloroformic acid ethyl ester; triethylamine in diethyl ether T=-78 - 0°C; 1 h; 2: methyl triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78 - 0°C;
参考文献
WO2006/17357 A1, ;
Page/Page column 14 ;
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; 2: C15H28O7Si in tetrahydrofuran; hexane T=-78°C; 3 h;
参考文献
WO2011/141934 A1, ;
Page/Page column 16-17; 18-20 ;
反应条件
n-butyllithium; sodium hydrogencarbonate; triethylamine in tetrahydrofuran
参考文献
US5260440 A1, ;
US 5260440 A
反应条件
potassium carbonate in dichloromethane T=10 - 27°C; Wittig Reaction; Product distribution / selectivity;
参考文献
US2012/310000 A1, ;
Page/Page column 12 ;
反应条件
1.1: n-butyllithium; triphenylemethane; N-pyrrolidinylnorephedrine / toluene; hexane; tetrahydrofuran / 2 h / -78 °C 1.2: 3 h 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate 3.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice 3.3: pH 6.5 4.1: triethylamine / hexane / 3 h / -40 °C 5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C 5.2: 3 h / -78 °C View Scheme
反应条件
1: sodium cyanide / water / 30 - 45 °C 2: hydrogenchloride / 20 °C 3: 1H-imidazole / dichloromethane / 25 - 30 °C 4: N-bromosuccinmide / acetone / -10 - 15 °C 5: sodium hydrogencarbonate; sodium hypochlorite; Aliquatreg; 336; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / -10 - 20 °C 6: potassium carbonate / dichloromethane / -10 - 10 °C View Scheme
反应条件
1: hydrogenchloride / 20 °C 2: 1H-imidazole / dichloromethane / 25 - 30 °C 3: N-bromosuccinmide / acetone / -10 - 15 °C 4: sodium hydrogencarbonate; sodium hypochlorite; Aliquatreg; 336; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / -10 - 20 °C 5: potassium carbonate / dichloromethane / -10 - 10 °C View Scheme
反应条件
1: 1H-imidazole / dichloromethane / 25 - 30 °C 2: N-bromosuccinmide / acetone / -10 - 15 °C 3: sodium hydrogencarbonate; sodium hypochlorite; Aliquatreg; 336; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / -10 - 20 °C 4: potassium carbonate / dichloromethane / -10 - 10 °C View Scheme
