4-(4-氟苯基)-6-异丙基-2-[(N-甲基-N-甲磺酰)氨基]嘧啶-5-甲醛合成路线 （共 37 条）
反应条件
1: With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide Kornblum Oxydation; 25 h; 2: With acetic anhydride; dimethyl sulfoxide T=70°C;
参考文献
WO2012/13325 A1, ;
Page/Page column 63 ;
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; oxygen; dmgH2; cobalt(II) nitrate hexahydrate in dichloromethane T=70°C; P=3000.3 Torr; 3 h; Autoclave;
参考文献
Heterocyclic Communications, , vol. 20, # 1 p. 11 - 13
反应条件
Oxonereg;; water; sodium hydrogencarbonate; RuCl3 monohydrate in acetonitrile T=20°C; 24 h;
参考文献
WO2012/13325 A1, ;
Page/Page column 64 ;
反应条件
acetic acid in water T=60 - 70°C; 0.166667 h;
参考文献
WO2006/128954 A1, ;
Page/Page column 11 ;
反应条件
1: With diisobutylaluminium hydride in dichloromethane T=0 - 5°C; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water T=0 - 30°C;
参考文献
WO2012/172564 A1, ;
Page/Page column 21-22 ;
反应条件
1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methanesulfonyl chloride in N,N-dimethyl-formamide T=0 - 20°C; 3.5 h;
参考文献
European Journal of Organic Chemistry, , # 5 p. 847 - 853
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide T=20°C; Kornblum oxidation; 71 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
1: potassium carbonate / acetone / 24 h / 20 °C 2: caesium carbonate / 2-methyl tetrahydrofuran / 10 h / 40 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 6: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme
反应条件
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 3: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 4: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme
反应条件
1: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 2: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 3: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme
