4-(4-氟苯基)-6-异丙基-2-[(N-甲基-N-甲磺酰)氨基]嘧啶-5-甲醛合成路线 （共 37 条）
反应条件
1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3: N-bromosuccinmide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere 2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; ammonia / toluene; water / 0 - 35 °C / Inert atmosphere 2.1: copper(l) chloride; sulfuric acid / methanol / 30 - 70 °C / Inert atmosphere; Reflux 3.1: potassium carbonate; tert.-butylhydroperoxide; CuCl2·2H2O / dichloromethane / 25 - 30 °C / Inert atmosphere 4.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere 5.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux 6.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere 6.2: 0 - 30 °C View Scheme
反应条件
1.1: copper(l) chloride; sulfuric acid / methanol / 30 - 70 °C / Inert atmosphere; Reflux 2.1: potassium carbonate; tert.-butylhydroperoxide; CuCl2·2H2O / dichloromethane / 25 - 30 °C / Inert atmosphere 3.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere 4.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux 5.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere 5.2: 0 - 30 °C View Scheme
反应条件
1.1: potassium carbonate; tert.-butylhydroperoxide; CuCl2·2H2O / dichloromethane / 25 - 30 °C / Inert atmosphere 2.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere 3.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux 4.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere 4.2: 0 - 30 °C View Scheme
反应条件
1.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere 2.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux 3.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere 3.2: 0 - 30 °C View Scheme
反应条件
1: N-bromosuccinmide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-bromosuccinmide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 68, # 9 p. 2155 - 2160
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-75 - -10°C; Julia-Kocienski Olefination; 2 h;
参考文献
WO2012/98048 A1, ;
Page/Page column 18-19 ;
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-75 - -10°C; Julia-Kocienski Olefination; 2.33333 h;
参考文献
WO2012/98048 A1, ;
Page/Page column 17-18 ;
