2-(4-氯-2-硝基苯基)基丙二酸二甲酯合成路线 （共 9 条）
反应条件
sodium hydride 1) DMSO, 100 deg C, 40 min, 2a) RT, 30 min, 2b) 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: WO2003/99198 A2, 2003 ;
Location in patent: Page 12 ;
反应条件
1: malonic acid dimethyl ester With potassium tert-butylate in N,N-dimethyl-formamide T=90°C; 0.166667 h; 2: 4-chloro-1-fluoro-2-nitro-benzene in N,N-dimethyl-formamide T=90°C; 2 h;
参考文献
Cheng, Mou-Nuo; Wang, Hao; Gong, Liu-Zhu
Organic Letters, 2011 , vol. 13, # 9 p. 2418 - 2421
反应条件
hydrogenchloride; acetic acid in water; acetic acid T=20 - 100°C; 6 h;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: WO2003/99198 A2, 2003 ;
Location in patent: Page 12 ;
反应条件
lithium chloride in water; dimethyl sulfoxide T=100°C; 3 h;
参考文献
Quallich; Morrissey
Synthesis, 1993 , # 1 p. 51 - 53
反应条件
iron; acetic acid in anhydrous xylene T=25 - 105°C; Large scale;
参考文献
WO2013/93928 A1, ;
Page/Page column 49; 50 ;
反应条件
1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere 3.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 3.2: 0 - 35 °C / Inert atmosphere 4.1: sodium carbonate / water / 25 - 100 °C View Scheme
参考文献
ARCH PHARMALABS LIMITED; GHOGARE, Bhausaheb Nana; DESHPANDE, Uday K.; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; CHARANJIT, Sehgal; NEHA, Dixit Akshaya
Patent: WO2012/20424 A1, 2012 ;
反应条件
1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere 3.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 3.2: 0 - 35 °C / Inert atmosphere View Scheme
反应条件
1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere View Scheme
参考文献
ARCH PHARMALABS LIMITED; GHOGARE, Bhausaheb Nana; DESHPANDE, Uday K.; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; CHARANJIT, Sehgal; NEHA, Dixit Akshaya
Patent: WO2012/20424 A1, 2012 ;
反应条件
1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere 3.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 3.2: 0 - 35 °C / Inert atmosphere 4.1: sodium carbonate / water / 25 - 100 °C View Scheme
参考文献
ARCH PHARMALABS LIMITED; GHOGARE, Bhausaheb Nana; DESHPANDE, Uday K.; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; CHARANJIT, Sehgal; NEHA, Dixit Akshaya
Patent: WO2012/20424 A1, 2012 ;
