2-氨基-6-溴-5-甲基苯甲酸合成路线 （共 4 条）
反应条件
sodium hydroxide; dihydrogen peroxide T=80°C; 1 h;
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
1: 76 percent / sodium sulfate, conc. HCl, hydroxylamine hydrochloride / H2O / 1 h / 100 °C 2: 50.7 percent / conc. H2SO4 / 1 h / 80 °C 3: 98 percent / 3 N aq. NaOH, 30percent H2O2 / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746
反应条件
triethylamine in tert-butyl methyl ether; N,N-dimethyl-formamide T=4 - 70°C; 13.1667 h; Large scale;
参考文献
Malmgren, Hakan; Baeckstroem, Birthe; Solver, Ellen; Wennerberg, Johan
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1195 - 1200
反应条件
1: 71.4 percent / sulfuric acid / H2O / 0.33 h / Heating 2: 75.3 percent / potassium hydroxide; 4-mercaptopyridine / ethane-1,2-diol / 2 h / Heating View Scheme
参考文献
Chen, Wei-Min; Wan, Shan-He
Synthetic Communications, 2007 , vol. 37, # 1 p. 53 - 61
