2-三氟甲基-4-氨基吡啶合成路线 （共 8 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol; water T=20°C; 6 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
palladium 10 on activated carbon; hydrogen in methanol; water T=20°C; 6 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
hydrogen; palladium on activated carbon in ethanol; dichloromethane
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5430148 A1, 1995 ;
US 5430148 A
反应条件
hydrogen; palladium on activated charcoal in ethanol P=1810.02 Torr; 0.75 h;
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
ammonia T=100°C; P=5171.48 Torr; 14 h;
参考文献
Hedge, Vidyadhar B.; Renga, James M.; Owen, John M.
Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1847 - 1850
反应条件
1: H2O2, acetic acid 2: 89 percent / H2 / 10percent Pd/C / aq. ethanol / 0.75 h / 1810.02 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746
反应条件
1: H2, N,N-dimethylethylamine / 10percent Pd/C / methyl acetate / 1.5 h 2: H2O2, acetic acid 3: 89 percent / H2 / 10percent Pd/C / aq. ethanol / 0.75 h / 1810.02 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746
反应条件
pyridine in tetrahydrofuran
T=20°C;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
