N-[(4S,6S)-6-甲基-7,7-二氧代-2-磺酰胺基-5,6-二氢-4H-噻吩并[2,3-b]噻喃-4-基]乙酰胺合成路线 （共 4 条）
反应条件
1.1: thionyl chloride; sulfuryl dichloride / 10 h / 28 °C / |Inert atmosphere 2.1: ammonia / methanol; acetone / -10 °C / |Inert atmosphere 3.1: Na2WO4·2H2O / methanol; water / 47 h / 10 - 50 °C / |Inert atmosphere 4.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / |Inert atmosphere 4.2: 2 h / 40 °C 5.1: methanesulfonic acid / water; acetonitrile / 19 h / 10 - 87 °C / |Inert atmosphere; |Reflux 5.2: 4 h / 7 - 40 °C / pH 7.3 View Scheme
反应条件
1.1: ammonia / methanol; acetone / -10 °C / |Inert atmosphere 2.1: Na2WO4·2H2O / methanol; water / 47 h / 10 - 50 °C / |Inert atmosphere 3.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / |Inert atmosphere 3.2: 2 h / 40 °C 4.1: methanesulfonic acid / water; acetonitrile / 19 h / 10 - 87 °C / |Inert atmosphere; |Reflux 4.2: 4 h / 7 - 40 °C / pH 7.3 View Scheme
反应条件
1.1: Na2WO4·2H2O / methanol; water / 47 h / 10 - 50 °C / |Inert atmosphere 2.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / |Inert atmosphere 2.2: 2 h / 40 °C 3.1: methanesulfonic acid / water; acetonitrile / 19 h / 10 - 87 °C / |Inert atmosphere; |Reflux 3.2: 4 h / 7 - 40 °C / pH 7.3 View Scheme
反应条件
1.1: sodium tetrahydroborate / water; tetrahydrofuran / 2 h / 15 °C / |Inert atmosphere 1.2: 2 h / 40 °C 2.1: methanesulfonic acid / water; acetonitrile / 19 h / 10 - 87 °C / |Inert atmosphere; |Reflux 2.2: 4 h / 7 - 40 °C / pH 7.3 View Scheme
