5-乙炔基-1-(2’,3’,5’-三-O-叔-丁基二甲基硅烷基-beta-D-呋喃核糖基)咪唑并-4-甲腈合成路线 （共 2 条）
反应条件
1: 76 percent / ammonia / methanol / 3 h / 120 °C 2: tetrabutylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Minakawa, Noriaki; Matsuda, Akira
Tetrahedron, 1993 , vol. 49, # 3 p. 557 - 570
反应条件
Multi-step reaction with 5 steps 1: 3.52 g / K2CO3 / dimethylformamide / 2.5 h / 80 °C2: 70 percent / ethylenediamine / 6 h / 50 °C3: 95 percent / p-toluenesulfonyl chloride; pyridine / 20 h / 20 °C4: 60 percent / diiodomethane; isoamyl nitrite / 0.75 h / 100 °C5: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C
参考文献
Erlacher, Matthias D.; Lang, Kathrin; Wotzel, Brigitte; Rieder, Renate; Micura, Ronald; Polacek, Norbert Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4453 - 4459
