2-氨甲基-3,4-二氯苯胺合成路线 （共 6 条）
反应条件
sodium hydroxide in hydrogenchloride; dichloromethane; water
参考文献
Roberts Laboratories Inc.
Patent: US6194420 B1, 2001 ;
反应条件
potassium borohydride; trifluoroacetic acid in tetrahydrofuran T=20°C; 3 h;
参考文献
Peters, Jens-Uwe; Luebbers, Thomas; Alanine, Alexander; Kolczewski, Sabine; Blasco, Francesca; Steward, Lucinda
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 256 - 261
反应条件
1: 91 percent / SnCl2, conc. HCl / 75 - 81 °C 2: KBH4, TFA / tetrahydrofuran / 6 h / Ambient temperature View Scheme
参考文献
Journal fur Praktische Chemie - Chemiker - Zeitung, , vol. 338, # 7 p. 675 - 678
参考文献
Roberts Laboratories Inc.
Patent: US6194420 B1, 2001 ;
反应条件
in toluene T=20 - 75°C; 2.5 h; Reflux;
参考文献
Scott, Richard B.; Downey, Kristin M.; Healy, Keith P.; Henderson, Alistair P.; Robinson, Claire L.; Clegg, William; Harrington, Ross W.; Franklin, Richard; Golding, Bernard T.
Heterocycles, 2012 , vol. 86, # 2 p. 1637 - 1646
参考文献
Peters, Jens-Uwe; Luebbers, Thomas; Alanine, Alexander; Kolczewski, Sabine; Blasco, Francesca; Steward, Lucinda
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 256 - 261
