8-硝基-7-甲基氨基喹啉合成路线 （共 6 条）
反应条件
1: 7-amino-8-nitroquinoline With sodium hydride in tetrahydrofuran; mineral oil T=20°C; 0.5 h; 2: methyl iodide in tetrahydrofuran; mineral oil T=20°C; 5 h;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 42 ;
US 20120178748 A1
参考文献
Ronne, Erik; Grivas, Spiros
Heterocycles, 1993 , vol. 36, # 1 p. 101 - 105
反应条件
potassium permanganate; methylamine T=-7°C; 4 h;
参考文献
Liebigs Annalen der Chemie, , # 8 p. 823 - 830
反应条件
potassium permanganate T=-7°C; 4 h;
参考文献
Liebigs Annalen der Chemie, , # 8 p. 823 - 830
反应条件
1.1: potassium tert-butylate; 1,1,1-trimethylhydrazinium iodide / dimethyl sulfoxide / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 2.2: 5 h / 20 °C View Scheme
参考文献
US2012/178748 A1, ;
US 20120178748 A1
反应条件
in ethanol 24 h; Ambient temperature;
参考文献
Wozniak, Marian; Grzegozek, Maria
Liebigs Annalen der Chemie, 1993 , # 8 p. 823 - 830
