2-(2-甲氧基-2-氧代乙基)苯甲酸合成路线 （共 26 条）
反应条件
1: With borane in tetrahydrofuran T=-15 - 20°C; 16 h; 2: With toluene-4-sulfonic acid in toluene T=80°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 21 p. 7241 - 7257
反应条件
borane in tetrahydrofuran T=-15 - 20°C; 16 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 21 p. 7241 - 7257
反应条件
oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Padwa; Beall; Eidell; Worsencroft
Journal of Organic Chemistry, 2001 , vol. 66, # 7 p. 2414 - 2421
反应条件
1.1: selenium(IV) oxide / 6 h / |Reflux 2.1: tetrahydrofuran / 3 h / 50 °C 2.2: 20 - 50 °C 3.1: potassium hydroxide / methanol; tetrahydrofuran; water / 1.5 h / 40 °C View Scheme
参考文献
Koza, Gani; Keskin, Selbi; Oezer, Merve Sinem; Cengiz, Betuel; Sahin, Ertan; Balci, Metin
Tetrahedron, 2013 , vol. 69, # 1 p. 395 - 409
反应条件
1: aqueous ammonia 2: bromine; KOH-solution View Scheme
参考文献
Wegscheider; Glogau
Monatshefte fuer Chemie, 1903 , vol. 24, p. 957
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / acetonitrile / 4 h / 0 - 23 °C
2: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; toluene / 1 h / 23 °C
View Scheme
参考文献
Kunchithapatham, Kamala; Eichman, Chad C.; Stambuli, James P.
Chemical Communications, 2011 , vol. 47, # 47 p. 12679 - 12681
反应条件
potassium carbonate in N,N-dimethyl-formamide
1 h; Ambient temperature;
参考文献
Hutchings, Michael G.; Chippendale, A. Margaret; Ferguson, Ian
Tetrahedron, 1988 , vol. 44, # 12 p. 3727 - 3734
反应条件
sodium hydride in tetrahydrofuran
参考文献
Kjaer, Anders; Kjaer, Dana
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 6 p. 417 - 419
反应条件
sodium in xylene
T=100°C; 1 h;
参考文献
Kjaer, Dana; Kjaer, Anders; Risbjerg, Elisabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2815 - 2820
反应条件
1.1: selenium(IV) oxide / 6 h / |Reflux
2.1: methanol / 4 h / 70 °C
2.2: 70 °C
3.1: potassium hydroxide / methanol; tetrahydrofuran; water / 1.5 h / 40 °C
View Scheme
参考文献
Koza, Gani; Keskin, Selbi; Oezer, Merve Sinem; Cengiz, Betuel; Sahin, Ertan; Balci, Metin
Tetrahedron, 2013 , vol. 69, # 1 p. 395 - 409
