2-乙氧基-1-((2-(n-羟基甲脒基)-[1,1-联苯]-4-基)甲基)-1H-苯并[d]咪唑-7-羧酸甲酯合成路线 （共 17 条）
反应条件
hydroxylamine hydrochloride; sodium hydrogencarbonate in dimethyl sulfoxide T=80 - 85°C; 20 h; Reagent/catalystSolventTemperatureTime;
参考文献
RANBAXY LABORATORIES LIMITED; AZAD, Md Abul Kalam; KSHIRSAGAR, Prakash Bhimaji; SINGH, Shravan, Kumar; TIWARI, Anand, Prakash; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/114305 A1, 2013 ;
Location in patent: Page/Page column 15; 16 ;
反应条件
potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=20°C; 4 h; Product distribution / selectivity;
参考文献
WO2012/139535 A1, ;
Page/Page column 12-13 ;
反应条件
hydroxylamine hydrochloride; triethylamine in dimethyl sulfoxide 0.5 h; Product distribution / selectivity;
参考文献
WO2012/119573 A1, ;
Page/Page column 12-13 ;
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C 2.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C 2.2: 0.5 h / 20 - 25 °C / pH 2 - 3 3.1: 4-(N,N-dimethlyamino)pyridine; potassium carbonate; p-toluoylsulfonylchloride / isobutyramide / -15 - 25 °C 3.2: 0.5 h / pH 4 - 5 View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
反应条件
1: With pyridine in N,N-dimethyl-formamide 6 h; Inert atmosphereCooling with ice-cold bath; 2: With potassium tert-butylate in dimethyl sulfoxide T=20°C; 5 h; 3: With hydrogenchloride in water; dimethyl sulfoxide
参考文献
ZENTIVA, K.S.; RADL, Stanislav; STACH, Jan
Patent: WO2012/139535 A1, 2012 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: With potassium tert-butylate in dimethyl sulfoxide T=100°C; 4 h; 2: With hydrogenchloride in water; dimethyl sulfoxide Product distribution / selectivity;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: pyridine / dimethylformamide / 0.5 h / 0 °C 2: xylene / 2 h / Heating 3: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme
参考文献
ZENTIVA, K.S.; RADL, Stanislav; STACH, Jan
Patent: WO2012/139535 A1, 2012 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=20°C; 4 h;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 18-19 ;
反应条件
triethylamine in tetrahydrofuran T=80°C; 8 h;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 21-22 ;
反应条件
carbon; triethylamine in tetrahydrofuran T=20 - 100°C; 5 h;
参考文献
ZENTIVA, K.S.; RADL, Stanislav
Patent: WO2012/139536 A1, 2012 ;
Location in patent: Page/Page column 22-23 ;
