2-(1H-1,3-苯并咪唑-2-基)乙酸乙酯合成路线 （共 17 条）
反应条件
in methanol T=0°C; 1.91667 h; RefluxInert atmosphere;
参考文献
Ginzinger, Werner; Muehlgassner, Gerhard; Arion, Vladimir B.; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Reithofer, Michael; Berger, Walter; Keppler, Bernhard K.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3398 - 3413
参考文献
Shenyang J and Health Pharmaceutical Co., Ltd.
Patent: EP2468730 A1, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
thionyl chloride T=0°C; Reflux;
参考文献
Yang, Peng Hui; Zhang, Qun Zheng; Yu, Hong Jiang
Research on Chemical Intermediates, 2012 , vol. 38, # 7 p. 1403 - 1409
反应条件
hydrogenchloride 1.5 h; Heating;
参考文献
Zakhs; Ponyaev; Subbotina; El'tsov
Russian Journal of General Chemistry, 2001 , vol. 71, # 7 p. 1076 - 1087
参考文献
Journal of the American Chemical Society, , vol. 65, p. 1072
反应条件
1: thionyl chloride / diethyl ether; water / 6 h / 0 - 20 °C / Inert atmosphere 2: methanol / 1.92 h / 0 °C / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 7 p. 3398 - 3413
反应条件
lithium diisopropyl amide 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 2 h, b) RT, 1 h; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 32, # 10 p. 1923 - 1931
反应条件
piperidine in N,N-dimethyl-formamide T=130°C; 4 h; Microwave irradiationSealed tube; Reagent/catalystSolventTemperatureTime;
参考文献
Klshore Babu; Tasqeeruddln; Ramadevi; Dubey
Indian Journal of Heterocyclic Chemistry, 2012 , vol. 21, # 4 p. 289 - 292
反应条件
hydrazine hydrate in ethanol 0.5 h; Heating;
参考文献
Rida; Labouta; Salama; Ghany; el-Ghazzaui; Kader
Pharmazie, 1986 , vol. 41, # 7 p. 475 - 478
反应条件
morpholine in ethanol
Reflux;
参考文献
Yang, Peng Hui; Zhang, Qun Zheng; Yu, Hong Jiang
Research on Chemical Intermediates, 2012 , vol. 38, # 7 p. 1403 - 1409
