1-Boc-3-苯基吡咯烷合成路线 （共 6 条）
反应条件
1: 4-phenyl-pyrrolidin-2-one With lithium aluminium tetrahydride in tetrahydrofuran 6 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran 3: di-tert-butyl dicarbonate in tetrahydrofuran; water 3 h;
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS
Patent: WO2007/119463 A1, 2007 ;
Location in patent: Page/Page column 204-205 ;
WO 2007/119463 A1
反应条件
hydrogen; palladium on activated charcoal in methanol P=2250.18 Torr; 24 h;
参考文献
stergaard, Niels; Thoning Pedersen, Brian; Skjaerbaek, Niels; Vedso, Per; Begtrup, Mikael
Synlett, 2002 , # 11 p. 1889 - 1891
反应条件
1: 61 percent / NMP / Fe(acac)3 / tetrahydrofuran / 0.5 h / 0 °C 2: RuCl2(PCy3)(1,3-bis-Mes-imidazolidin-2-yl)(=CHPh) / CH2Cl2 / 24 h / 20 °C 3: H2 / 10 percent Pd/C / methanol / 24 h / 2250.18 Torr View Scheme
参考文献
stergaard, Niels; Thoning Pedersen, Brian; Skjaerbaek, Niels; Vedso, Per; Begtrup, Mikael
Synlett, 2002 , # 11 p. 1889 - 1891
反应条件
1: RuCl2(PCy3)(1,3-bis-Mes-imidazolidin-2-yl)(=CHPh) / CH2Cl2 / 24 h / 20 °C 2: H2 / 10 percent Pd/C / methanol / 24 h / 2250.18 Torr View Scheme
参考文献
stergaard, Niels; Thoning Pedersen, Brian; Skjaerbaek, Niels; Vedso, Per; Begtrup, Mikael
Synlett, 2002 , # 11 p. 1889 - 1891
反应条件
1: 1) t-BuLi / 1) THF, pentane, -30 to -25 deg C, 6 h 2: 95 percent / conc. HCl / tetrahydrofuran / 0.25 h / Ambient temperature 3: 85 percent / H2 / 10percent Pd-C / ethanol / 6 h / 2068.6 Torr View Scheme
参考文献
Clark, Robin D.; Jahangir
Tetrahedron, 1993 , vol. 49, # 7 p. 1351 - 1356
反应条件
1: With hydrogenchloride in ethyl acetate 2 h; 2: With potassium carbonate in diethyl ether; water
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS
Patent: WO2007/119463 A1, 2007 ;
Location in patent: Page/Page column 204; 205 ;
WO 2007/119463 A1
