1-叔丁氧羰基-4-甲氨基哌啶合成路线 （共 5 条）
反应条件
in dichloromethane T=20°C; 16 h;
参考文献
VERNALIS (OXFORD) LIMITED; LABORATOIRES SERONO S.A.
Patent: WO2005/19194 A1, 2005 ;
Location in patent: Page/Page column 35 ;
WO 2005/019194 A1
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2008/71646 A1, 2008 ;
Location in patent: Page/Page column 79 ;
WO 2008/071646 A1
反应条件
1.1: dichloromethane / 1 h / 20 °C 1.2: 14 h / 0 - 20 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
1.1: HATU / dichloromethane / 0.5 h / 20 °C
1.2: 20 °C
2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; WITTY, David R.; NORTON, David; TIERNEY, Jason Paul; LORTHIOIR, Ghislaine; SIME, Mairi; PHILPOTT, Karen Louise
Patent: WO2012/80735 A1, 2012 ;
WO 2012/080735 A1
反应条件
1: With triethylamine in dichloromethane
T=0°C; 0.5 h;
2: With trifluoroacetic acid in dichloromethane
3 h;
3: With sodium hydrogencarbonate in dichloromethane; water
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2009/53716 A1, 2009 ;
Location in patent: Page/Page column 101 ;
WO 2009/053716 A1
