反应条件
1.1: 92 percent / p-toluenesulfonic acid monohydrate / benzene / 5 h / Heating
2.1: t-BuLi / diethyl ether / 1 h / -78 °C
2.2: 68 percent / diethyl ether / 4 h / -78 °C
3.1: aq. HCO2H / 18 h / 20 °C
4.1: 168 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH2Cl2 / 0 °C
View Scheme
参考文献
Wishka, Donn G.; Walker, Daniel P.; Yates, Karen M.; Reitz, Steven C.; Jia, Shaojuan; Myers, Jason K.; Olson, Kirk L.; Jacobsen, E. Jon; Wolfe, Mark L.; Groppi, Vincent E.; Hanchar, Alexander J.; Thornburgh, Bruce A.; Cortes-Burgos, Luz A.; Wong, Erik H. F.; Staton, Brian A.; Raub, Thomas J.; Higdon, Nicole R.; Wall, Theron M.; Hurst, Raymond S.; Walters, Rodney R.; Hoffmann, William E.; Hajos, Mihaly; Franklin, Stanley; Carey, Galen; Gold, Lisa H.; Cook, Karen K.; Sands, Steven B.; Zhao, Sabrina X.; Soglia, John R.; Kalgutkar, Amit S.; Arneric, Stephen P.; Rogers, Bruce N.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4425 - 4436