(alphaR)-alpha-[[(1,1-二甲基乙氧基)羰基]甲基氨基]-2-萘丙酸合成路线 （共 4 条）
反应条件
lithium hydroxide in 1,4-dioxane; water; ethyl acetate
参考文献
Novo Nordisk A/S
Patent: US6350767 B1, 2002 ;
Location in patent: Page column 107 ;
反应条件
sodium hydride in tetrahydrofuran 24 h; Ambient temperature;
参考文献
Haviv; Fitzpatrick; Swenson; Nichols; Mort; Bush; Diaz; Bammert; Nguyen; Rhutasel; Nellans; Hoffman; Johnson; Greer
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 363 - 369
反应条件
lithium hydroxide in 1,4-dioxane; water; ethyl acetate
参考文献
Novo Nordisk A/S
Patent: US6013658 A1, 2000 ;
反应条件
1: 1.) 1-hydroxy-7-azabenzotriazole, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 2.) diisopropylethylamine / 1.) CH2Cl2, DMF, 15 min, 2.) CH2Cl2, DMF, overnight 2: 87 percent / TFA / CH2Cl2 / 0.17 h 3: 1.) 1-hydroxy-7-azabenzotriazole, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, 2.) diisopropylethylamine / 1.) CH2Cl2, DMF, 15 min, 2.) CH2Cl2, DMF, overnight 4: 41 percent / TFA / CH2Cl2 / 0.12 h View Scheme
参考文献
Hansen, Thomas K.; Ankersen, Michael; Hansen, Birgit S.; Raun, Kirsten; Nielsen, Karin K.; Lau, Jesper; Peschke, Bernd; Lundt, Behrend F.; Thogersen, Henning; Johansen, Nils L.; Madsen, Kjeld; Andersen, Peter H.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3705 - 3714
