4-羟基-5,8-二甲氧基-2-萘羧酸乙酯合成路线 （共 8 条）
反应条件
potassium carbonate in ethanol T=70°C; 1 h;
参考文献
Tamiya, Minora; Ohmori, Ken; Kitamura, Mitsuru; Kato, Hirohisa; Arai, Tadamasa; Oorui, Mami; Suzuki, Keisuke
Chemistry - A European Journal, 2007 , vol. 13, # 35 p. 9791 - 9823
反应条件
1: anhydrous diethyl succinate With ethanol; sodium hydride in toluene T=40°C; deprotonation; 2: 2,5-dimethoxy-benzaldehyde With sodium acetate in acetic anhydride Condensation; Stobbe; Heating; 3: With hydrogenchloride in ethanol deacetylation; Heating;
参考文献
Couladouros, Elias A.; Strongilos, Alexandros T.
Tetrahedron Letters, 2000 , vol. 41, # 4 p. 535 - 538
反应条件
1: 94 percent / K2CO3 / acetone / 16 h / Heating
2: 160 °C
3: 0.77 g / K2CO3 / acetone / 16 h / Heating
4: 93 percent / LiAlH4 / tetrahydrofuran / 20 °C
View Scheme
参考文献
De Koning, Charles B.; Manzini, Sunnyboy S.; Michael, Joseph P.; Mmutlane, Edwin M.; Tshabidi, Tefo R.; Van Otterlo, Willem A.L.
Tetrahedron, 2005 , vol. 61, # 3 p. 555 - 564
反应条件
1: 78 percent / K2CO3; KI / acetone / 16 h / Heating
2: 160 °C
3: 0.70 g / K2CO3 / acetone / 16 h / Heating
4: 89 percent / LiAlH4 / tetrahydrofuran / 20 °C
View Scheme
参考文献
De Koning, Charles B.; Manzini, Sunnyboy S.; Michael, Joseph P.; Mmutlane, Edwin M.; Tshabidi, Tefo R.; Van Otterlo, Willem A.L.
Tetrahedron, 2005 , vol. 61, # 3 p. 555 - 564
反应条件
1: 83 percent / K2CO3 / acetone / 16 h / Heating
2: 160 °C
3: 0.69 g / K2CO3 / acetone / 16 h / Heating
4: 86 percent / LiAlH4 / tetrahydrofuran / 20 °C
View Scheme
参考文献
De Koning, Charles B.; Manzini, Sunnyboy S.; Michael, Joseph P.; Mmutlane, Edwin M.; Tshabidi, Tefo R.; Van Otterlo, Willem A.L.
Tetrahedron, 2005 , vol. 61, # 3 p. 555 - 564
反应条件
1: 94 percent / K2CO3 / acetone / 16 h / Heating
2: 160 °C
3: 0.77 g / K2CO3 / acetone / 16 h / Heating
4: 93 percent / LiAlH4 / tetrahydrofuran / 20 °C
5: 74 percent / DMSO; trifluoroacetic anhydride; Et3N / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
De Koning, Charles B.; Manzini, Sunnyboy S.; Michael, Joseph P.; Mmutlane, Edwin M.; Tshabidi, Tefo R.; Van Otterlo, Willem A.L.
Tetrahedron, 2005 , vol. 61, # 3 p. 555 - 564
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.333333 h;
参考文献
Tamiya, Minora; Ohmori, Ken; Kitamura, Mitsuru; Kato, Hirohisa; Arai, Tadamasa; Oorui, Mami; Suzuki, Keisuke
Chemistry - A European Journal, 2007 , vol. 13, # 35 p. 9791 - 9823
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Kramer, Carsten S.; Nieger, Martin; Braese, Stefan
European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2150 - 2159
