3-(3,4-二羟基苯基)-6,8-二羟基异苯并吡喃-1-酮合成路线 （共 6 条）
反应条件
boron tribromide in dichloromethane
T=20°C; 72 h;
参考文献
Rossi, Renzo; Carpita, Adriano; Bellina, Fabio; Stabile, Paolo; Mannina, Luisa
Tetrahedron, 2003 , vol. 59, # 12 p. 2067 - 2081
反应条件
boron tribromide in dichloromethane
T=-78 - 20°C; Inert atmosphere;
参考文献
Kurume, Ai; Kamata, Yasuhiro; Yamashita, Masayuki; Wang, Qilong; Matsuda, Hisashi; Yoshikawa, Masayuki; Kawasaki, Ikuo; Ohta, Shunsaku
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 9 p. 1264 - 1269
反应条件
1: 94 percent / NaH / dimethylformamide / 2 h / 20 °C
2: 85 percent / ZnCl2; Pd2(dba)3; dppf / tetrahydrofuran / 17 h / 0 - 60 °C
3: 67 percent / I2 / acetonitrile / 2 h / 20 °C
4: 98 percent / formic acid; Et3N; PPh3 / Pd(OAc)2 / dimethylformamide / 60 - 63 °C
5: 81 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Bellina, Fabio; Stabile, Paolo; Mannina, Luisa
Tetrahedron, 2003 , vol. 59, # 12 p. 2067 - 2081
反应条件
1: 80 percent / BBr3 / CH2Cl2 / 0.67 h / -70 - 20 °C
2: 94 percent / NaH / dimethylformamide / 2 h / 20 °C
3: 85 percent / ZnCl2; Pd2(dba)3; dppf / tetrahydrofuran / 17 h / 0 - 60 °C
4: 67 percent / I2 / acetonitrile / 2 h / 20 °C
5: 98 percent / formic acid; Et3N; PPh3 / Pd(OAc)2 / dimethylformamide / 60 - 63 °C
6: 81 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Bellina, Fabio; Stabile, Paolo; Mannina, Luisa
Tetrahedron, 2003 , vol. 59, # 12 p. 2067 - 2081
反应条件
1: 67 percent / I2 / acetonitrile / 2 h / 20 °C
2: 98 percent / formic acid; Et3N; PPh3 / Pd(OAc)2 / dimethylformamide / 60 - 63 °C
3: 81 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Bellina, Fabio; Stabile, Paolo; Mannina, Luisa
Tetrahedron, 2003 , vol. 59, # 12 p. 2067 - 2081
反应条件
1: 99 percent / acetic acid / 3 h / Heating
2: BBr3 / various solvent(s) / Heating
View Scheme
参考文献
Ohta; Kamata; Inagaki; Masuda; Yamamoto; Yamashita; Kawasaki
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 6 p. 1188 - 1190
