1: 98 percent / H2SO4
2: 69 percent / NaOMe / dioxane / 45 h / 110 °C
3: 94 percent / water / aq. NaOH / dioxane / 17 h / 110 °C
4: 70 percent / PCC / CH2Cl2 / 2 h / Ambient temperature
5: 59 percent / BF3*MeOH / 17 h / Ambient temperature; reaction of its derivatives HCl too with sev. alcohols
6: 86 percent / BBr3 / CH2Cl2 / 16 h / -78 °C
View Scheme
参考文献
Martin, Tracey; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 235 - 240
1: 60 percent / Iodine, potassium iodide / methanol; H2O / Ambient temperature
2: 6.5 g / 10percent aq. NaOH / 1 h / Heating
View Scheme
参考文献
Nagarajan, K.; Arya, V. P.; Parthasarathy, T. N.; Shenoy, S. J.; Shah, R. K.; Kulkarni, Y. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 8 p. 672 - 679
1: With pyridin-4-yl methyl amine; diisopropyl-carbodiimide in dichloromethane
T=20°C;
2: With hydroxylamine in dichloromethane; water
T=20°C; Further stages.;
参考文献
Choi, Jinil; Park, Jewn Giew; Pang, Yuan-Ping
Tetrahedron Letters, 2008 , vol. 49, # 7 p. 1103 - 1106
1: 95 percent / conc. H2SO4 / 18 h / Heating
2: NaH / dimethylsulfoxide
View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
