2-甲氧基-4-(2-氨基乙基)苯酚合成路线 （共 14 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=0°C; P=760 Torr;
参考文献
Kohno; Sasao; Murahashi
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1252 - 1254
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=20°C; 12 h;
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: With borane-THF in tetrahydrofuran T=0°C; 8 h; Reflux; 2: With hydrogenchloride in water 3 h; Reflux;
参考文献
MILLER, James Jackson; PHILLIPS, Anthony George; LAPISH, Christopher Court; SAMMIS, Glenn Martin
Patent: WO2013/20229 A1, 2013 ;
Location in patent: Paragraph 0193 ;
WO 2013/020229 A1
反应条件
hydrogenchloride; hydrogen; iron(III) chloride; platinum in water 4 h;
参考文献
Kulikov, S. V.; Samartsev, M. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 2 p. 348 - 358
反应条件
1: 60 percent / dimethylformamide / 20 h / 130 °C 2: 82 percent / H2; HCl / Pd/C / ethanol / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 14 p. 3369 - 3373
反应条件
1: 71 percent / KOH, tetrabutylammonium bromide / ethanol / 1 h / 0 °C 2: 85 percent / AcONa. Ac2O / 0.08 h / Heating 3: 76 percent / conc. aq. HCl, FeCl3, H2 / Pt black / H2O / 4 h View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, , vol. 28, # 2 p. 348 - 358
反应条件
1: 100 percent / K2CO3, tetrabutylammonium bromide / dimethylformamide / 5 h / 18 - 20 °C 2: 71 percent / KOH, tetrabutylammonium bromide / ethanol / 1 h / 0 °C 3: 85 percent / AcONa. Ac2O / 0.08 h / Heating 4: 76 percent / conc. aq. HCl, FeCl3, H2 / Pt black / H2O / 4 h View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, , vol. 28, # 2 p. 348 - 358
反应条件
1: 85 percent / AcONa. Ac2O / 0.08 h / Heating 2: 76 percent / conc. aq. HCl, FeCl3, H2 / Pt black / H2O / 4 h View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, , vol. 28, # 2 p. 348 - 358
反应条件
hydrogenchloride T=70°C; Pictet-Spengler isoquinoline synthesis; 1 h;
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
ammonium hydroxide in water T=50°C; pH=9 - 10;
参考文献
MILLER, James Jackson; PHILLIPS, Anthony George; LAPISH, Christopher Court; SAMMIS, Glenn Martin
Patent: WO2013/20229 A1, 2013 ;
Location in patent: Paragraph 0193 ;
WO 2013/020229 A1
