2-(5-甲氧基-1H-吲哚-3-基)-2-氧代乙酸乙酯合成路线 （共 5 条）
反应条件
triethylamine T=0 - 20°C; 1 h;
参考文献
WO2012/110986 A1, ;
Page/Page column 51 ;
WO 2012/110986 A1
反应条件
triethylamine T=20°C; 12 h;
参考文献
Deslandes, Sebastien; Lamoral-Theys, Delphine; Frongia, Celine; Chassaing, Stefan; Bruyere, Celine; Lozach, Olivier; Meijer, Laurent; Ducommun, Bernard; Kiss, Robert; Delfourne, Evelyne
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 626 - 636
反应条件
1: diethyl ether / 4 h / 20 °C / Inert atmosphere 2: triethylamine / 12 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 54, p. 626 - 636
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C 2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 3.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 65°C; 0.333333 h; 2: With water in tetrahydrofuran; ethyl acetate
参考文献
WO2012/110986 A1, ;
Page/Page column 51 ;
WO 2012/110986 A1
