6-氯-2-甲基-3,4-二氢-2H-1-苯并噻因-4-酮合成路线 （共 3 条）
反应条件
1: With triethylamine in chlorobenzene T=80°C; 6 h; 2: With thionyl chloride in N,N-dimethyl acetamide; chlorobenzene T=50°C; 1 h; 3: With AlCl3, aluminium chloride in N,N-dimethyl acetamide; chlorobenzene T=8°C; 4 h;
参考文献
FUJIFILM Corporation; SAKITA, Kyouhei; KIKUCHI, Wataru; YUMOTO, Masatoshi; HIKITA, Masanori
Patent: US2013/171415 A1, 2013 ;
Location in patent: Paragraph 0472 ;
反应条件
methanesulfonic acid T=75°C; 0.5 h;
参考文献
Clayton, Stephen E.; Gabbutt, Christopher D.; Hepworth, John D.; Mark Heron
Tetrahedron, 1993 , vol. 49, # 4 p. 939 - 946
反应条件
1: 1.) NaH (60 percent in mineral oil) / 1.) THF, 2.) reflux, 2 h 2: 92 percent / methanesulphonic acid / 0.5 h / 75 °C View Scheme
参考文献
Clayton, Stephen E.; Gabbutt, Christopher D.; Hepworth, John D.; Mark Heron
Tetrahedron, 1993 , vol. 49, # 4 p. 939 - 946
