6,7-二氢-5H-吡咯并[3,4-b]吡啶合成路线 (共 9 条)
反应条件
hydrogen; 5 palladium over charcoal in ethanol T=60°C; P=2585.81 Torr; 3 h;
参考文献
PFIZER LIMITED
Patent: WO2006/123242 A1, 2006 ;
Location in patent: Page/Page column 40 ;
WO 2006/123242 A1
反应条件
2-toluenesulfonamide; sodium hydride in N,N-dimethyl-formamide
参考文献
Sperry, Jeffrey B.; Farr, Roger M.; Levent, Mahmut; Ghosh, Mousumi; Hoagland, Steven M.; Varsolona, Richard J.; Sutherland, Karen
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1854 - 1860
反应条件
1: sulfuric acid 2: sodium tetrahydroborate; hydrogenchloride / ethanol 3: thionyl chloride / toluene 4: 2-toluenesulfonamide; sodium hydride / N,N-dimethyl-formamide View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 11 p. 1854 - 1860
反应条件
1: sodium tetrahydroborate; hydrogenchloride / ethanol 2: thionyl chloride / toluene 3: 2-toluenesulfonamide; sodium hydride / N,N-dimethyl-formamide View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 11 p. 1854 - 1860
反应条件
1: thionyl chloride / toluene 2: 2-toluenesulfonamide; sodium hydride / N,N-dimethyl-formamide View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 11 p. 1854 - 1860
反应条件
triethylamine in dichloromethane
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00317 ;
参考文献
Bayer Aktiengesellschaft
Patent: US5312823 A1, 1994 ;
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: hydrogen; palladium 10 on activated carbon / 2-methoxy-ethanol / 6 h / 70 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 1.2: 5 h 2.1: hydrogen; palladium 10 on activated carbon / 2-methoxy-ethanol / 6 h / 70 °C / 15001.5 Torr View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;