bis(trimethyl-silyl)-trifluoroacetamide; trimethylsilyl iodide in dichloromethane 1.) 0 deg C, 1 h; 2.) room temp., 2 h; Yield given;

1: Et3N / tetrahydrofuran / 0.5 h / Ambient temperature 2: CBr4, Et3N / tetrahydrofuran / Ambient temperature 3: 5percent aq. NaHCO3/Na2SO3 / tetrahydrofuran; diethyl ether 4: bis(trimethylsilyl)trifluoroacetamide, trimethylsilyl iodide / CH2Cl2 / 1.) 0 deg C, 1 h; 2.) room temp., 2 h View Scheme

1: CBr4, Et3N / tetrahydrofuran / Ambient temperature 2: 5percent aq. NaHCO3/Na2SO3 / tetrahydrofuran; diethyl ether 3: bis(trimethylsilyl)trifluoroacetamide, trimethylsilyl iodide / CH2Cl2 / 1.) 0 deg C, 1 h; 2.) room temp., 2 h View Scheme

water; sodium carbonate; alkaline phosphatase T=37°C; pH=9.6; 0.5 h; Enzymatic reactionphosphate buffer; Product distribution / selectivity;

water; sodium carbonate; alkaline phosphatase T=37°C; pH=9.6; 0.5 h; Enzymatic reactionphosphate buffer; Product distribution / selectivity;