(+)-2-乙氧基-4-(N-3-甲基-1(S)-(2-(1-哌啶基)苯基)-丁基)羰基甲基)合成路线 （共 29 条）
反应条件
in N-methyl-acetamide; methanol
参考文献
Dr. Karl Thomae GmbH
Patent: US5312924 A1, 1994 ;
参考文献
Dr. Karl Thomae GmbH
Patent: US5312924 A1, 1994 ;
反应条件
1: N-acetyl-L-glutamic acid / acetone
2: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
View Scheme
参考文献
Kolla, Naveenkumar; Elati, Chandrashekar R.; Vankawala, Pravinchandra J.; Gangula, Srinivas; Sajja, Eswaraiah; Anjaneyulu, Yerremilli; Bhattacharya, Apurba; Sundaram, Venkataraman; Mathad, Vijayavitthal T.
Chimia, 2006 , vol. 60, # 9 p. 593 - 597
反应条件
1: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: aq. HCl / 5.5 h / Heating
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: (S)-1-(2-piperidino-phenyl)-3-methyl-1-butyl-N-4-methoxybenzyl-ammonium L-mandelate With sodium hydroxide; water in toluene
2: (2-ethoxy-4-ethoxycarbonyl-phenyl)acetic acid With 1,1'-carbonyldiimidazole in water; toluene; acetonitrile
Product distribution / selectivity;
参考文献
CILAG AG
Patent: WO2004/101540 A2, 2004 ;
Location in patent: Page/Page column 13-14 ;
反应条件
1: (S)-1-(2-piperidino-phenyl)-3-methyl-1-butyl-N-benzyl-ammonium L-mandelate With sodium hydroxide; water in toluene
2: (2-ethoxy-4-ethoxycarbonyl-phenyl)acetic acid With 1,1'-carbonyldiimidazole in water; toluene; acetonitrile
Product distribution / selectivity;
参考文献
CILAG AG
Patent: WO2004/101540 A2, 2004 ;
Location in patent: Page/Page column 15-16 ;
