10-(1-氮杂双环[2.2.2]辛-3-基甲基)-10H-吩噻嗪合成路线 （共 8 条）
反应条件
potassium tert-butylate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one 2.5 h; Inert atmosphereReflux;
参考文献
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES; PIERRE FABRE MEDICAMENT; Nicolas, Marc; Larquetoux, Laurent; Leroux, Sébastien; Doris, Eric
Patent: US2013/296553 A1, 2013 ;
Location in patent: Paragraph 0112; 0113; 0114 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 2.1: thionyl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere; Reflux 3.1: potassium carbonate; sodium iodide / acetonitrile / 2 h / Inert atmosphere; Reflux 4.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 4.3: -78 - 20 °C 5.1: pyridine / chloroform / Inert atmosphere 6.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
反应条件
1.1: potassium carbonate; sodium iodide / acetonitrile / 2 h / Inert atmosphere; Reflux 2.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 2.3: -78 - 20 °C 3.1: pyridine / chloroform / Inert atmosphere 4.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
反应条件
1.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 1.3: -78 - 20 °C 2.1: pyridine / chloroform / Inert atmosphere 3.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
反应条件
1.1: thionyl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere; Reflux 2.1: potassium carbonate; sodium iodide / acetonitrile / 2 h / Inert atmosphere; Reflux 3.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 3.3: -78 - 20 °C 4.1: pyridine / chloroform / Inert atmosphere 5.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
反应条件
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C / Inert atmosphere 1.2: 1.25 h / -78 - 20 °C / Inert atmosphere 2.1: potassium tert-butylate; oxygen / tetrahydrofuran / 0.67 h / 0 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 4.1: thionyl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere; Reflux 5.1: potassium carbonate; sodium iodide / acetonitrile / 2 h / Inert atmosphere; Reflux 6.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 6.3: -78 - 20 °C 7.1: pyridine / chloroform / Inert atmosphere 8.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
反应条件
1.1: potassium tert-butylate; oxygen / tetrahydrofuran / 0.67 h / 0 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 3.1: thionyl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere; Reflux 4.1: potassium carbonate; sodium iodide / acetonitrile / 2 h / Inert atmosphere; Reflux 5.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 5.3: -78 - 20 °C 6.1: pyridine / chloroform / Inert atmosphere 7.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
反应条件
1: pyridine / chloroform / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 13 p. 3549 - 3551
