2-氨基-5-甲基苯并噻唑合成路线 （共 16 条）
反应条件
1: With bromine in chloroform T=0 - 5°C; Reflux; 2: With ammonia in water
参考文献
Sharma, Pratibha; Kumar, Ashok; Kumari, Prerna; Singh, Jitendra; Kaushik
Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1136 - 1148
反应条件
iodine; oxygen; toluene-4-sulfonic acid in dimethyl sulfoxide T=75°C; P=760.051 Torr; 24 h; regioselective reaction;
参考文献
Zhao, Jinwu; Huang, Huawen; Wu, Wanqing; Chen, Huoji; Jiang, Huanfeng
Organic Letters, 2013 , vol. 15, # 11 p. 2604 - 2607
反应条件
Ni(PEt3)2Cl2; sodium cyanoborohydride in N,N-dimethyl-formamide T=60°C; 90 h;
参考文献
Takagi, Kentaro
Chemistry Letters, 1986 , p. 265 - 266
反应条件
bromine; acetic acid T=0 - 20°C;
参考文献
Patel, Navin B.; Agravat, Suresh N.; Shaikh, Faiyazalam M.
Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 1033 - 1041
参考文献
Gazzetta Chimica Italiana, , vol. 99, p. 362
Chemische Berichte, , vol. 100, p. 1394,1399
反应条件
bromine in acetic acid 24 h;
参考文献
Hays; Rice; Ortwine; Johnson; Schwarz; Boyd; Copeland; Vartanian; Boxer
Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 10 p. 1425 - 1432
反应条件
ammonium hydrogen sulfite; ammonium hydroxide T=150°C;
参考文献
Gazzetta Chimica Italiana, , vol. 76, p. 215,221
反应条件
1: hydrogenchloride / water / Heating 2: bromine / tetrachloromethane View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 48, # 6 p. 1351 - 1355
反应条件
1.1: hydrogenchloride / water / 0.5 h / Reflux 1.2: 4 h / 20 °C / Reflux 2.1: bromine / chloroform / 0 - 5 °C / Reflux View Scheme
参考文献
Medicinal Chemistry Research, , vol. 21, # 7 p. 1136 - 1148
反应条件
bromine; acetic acid T=0 - 20°C;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 45, # 11 p. 1343 - 1353
