1-噁-6-氮杂螺[2.5]辛烷-6-羧酸-1,1-二甲基乙酯合成路线 （共 17 条）
反应条件
1: trimethyl-sulfonium iodide With sodium hydride in dimethyl sulfoxide T=0 - 20°C; 0.666667 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in dimethyl sulfoxide T=20 - 55°C; 2.5 h; 3: With water in dimethyl sulfoxide T=0°C;
参考文献
TEIJIN LIMITED
Patent: EP1505067 A1, 2005 ;
Location in patent: Page/Page column 368 ;
EP 1505067 A1
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform T=0 - 20°C;
参考文献
ACHAOGEN, INC.; AGGEN, James, Bradley; DOZZO, Paola; GOLDBLUM, Adam, Aaron; HILDEBRANDT, Darin, James; KANE, Timothy, Robert; GLIEDT, Micah, James; LINSELL, Martin, Sheringham
Patent: WO2011/44501 A2, 2011 ;
Location in patent: Page/Page column 58; 67 ;
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/129007 A1, 2008 ;
Location in patent: Page/Page column 38 ;
WO 2008/129007 A1
反应条件
1: trimethyl-sulfonium iodide With sodium hydride in dimethyl sulfoxide T=5°C; 0.5 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in dimethyl sulfoxide T=20°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/79805 A1, 2005 ;
Location in patent: Page/Page column 72 ;
WO 2005/079805 A1
反应条件
potassium hydroxide in acetonitrile T=20°C; 48 h;
参考文献
SOLVAY PHARMACEUTICALS GmbH.
Patent: US2005/131004 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
US 20050131004 A1
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform T=0°C; 0.5 h;
参考文献
ACHAOGEN, INC.
Patent: WO2009/67692 A1, 2009 ;
Location in patent: Page/Page column 44; 140 ;
WO 2009/067692 A1
反应条件
in chloroform T=0 - 20°C;
参考文献
ACHAOGEN, INC.; BRUSS, Jon, B.; MILLER, George, H.; AGGEN, James, Bradley; ARMSTRONG, Eliana, Saxon
Patent: WO2010/132777 A2, 2010 ;
Location in patent: Page/Page column 146-147; 46 ;
反应条件
in dimethyl sulfoxide T=55°C; 6 h;
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: US2006/46991 A1, 2006 ;
Location in patent: Page/Page column 59-60 ;
US 20060046991 A1
反应条件
1: trimethyl sulfoxonium iodide With sodium hydride in dimethyl sulfoxide T=5 - 20°C; 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in dimethyl sulfoxide T=5 - 50°C; 1.5 h;
参考文献
WO2005/118587 A1, ;
Page/Page column 223-224 ;
WO 2005/118587 A1
反应条件
in dimethyl sulfoxide T=50°C; 2 h;
参考文献
WO2004/58763 A1, ;
Page 31 ;
WO 2004/058763 A1
