4-甲氧基-3-甲基苯酚合成路线 （共 25 条）
反应条件
lithium aluminium tetrahydride; iron (III) acetylacetonate; sodium t-butanolate in toluene T=160°C; 24 h; Inert atmosphere;
参考文献
Ren, Yunlai; Yan, Mengjie; Wang, Jianji; Zhang, Z. Conrad; Yao, Kaisheng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12674 - 12678
Angew. Chem., 2013 , vol. 125, # 48 p. 12906 - 12910
反应条件
potassium dihydrogenphosphate; Fremy’s salt in methanol
参考文献
Mazza,S. et al.
Journal of Organic Chemistry, 1974 , vol. 39, # 24 p. 3610 - 3611
反应条件
1: With dichloromethoxy methane; titanium tetrachloride in dichloromethane
T=20°C;
2: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
Heating;
3: With ammonium hydroxide in methanol
T=20°C;
参考文献
Lecornue, Frederic; Ollivier, Jean
Synlett, 2004 , # 9 p. 1613 - 1615
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; Baeyer-Villiger oxidation reaction; 14 h;
2: With sodium hydroxide in methanol
T=20°C; 5 h; Further stages.;
参考文献
Roy, Amalesh; Biswas, Bidyut; Sen, Prabir K.; Venkateswaran, Ramanathapuram V.
Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6933 - 6936
反应条件
hydrogenchloride in tetrahydrofuran
Hydrolysis; 10 h; Heating;
参考文献
Hauser, Frank M.; Ganguly, Debashis
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1842 - 1849
反应条件
Amberlyst-15
4 h; Reflux; Overall yield = 71 percent;
参考文献
Mondal, Rina; Guha, Chayan; Mallik, Asok K.
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 86 - 89
反应条件
1: With tri-isopropoxy-borane; lithium in diethyl ether
Substitution; Heating;
2: With tert.-butylhydroperoxide; ammonium chloride in water
Oxidation;
参考文献
Vyvyan, James R.; Looper, Ryan E.
Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1151 - 1154
反应条件
1: m-PCBA / CH2Cl2 / 12 h / Heating
2: 10percent aq. KOH / methanol
View Scheme
参考文献
Rathore, Rajendra; Kochi, Jay K.
Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7479 - 7490
反应条件
sodium hydroxide
T=10°C;
参考文献
Kharasch et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 925,927
反应条件
1.1: 96 percent / K2CO3 / acetone / 5 h / Heating
2.1: m-CPBA / CH2Cl2 / 14 h / 20 °C
2.2: 85 percent / NaOH / methanol / 5 h / 20 °C
View Scheme
参考文献
Roy, Amalesh; Biswas, Bidyut; Sen, Prabir K.; Venkateswaran, Ramanathapuram V.
Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6933 - 6936
