2-氟-3-氧代-3-苯丙酸乙酯合成路线 （共 18 条）
反应条件
toluene-4-sulfonic acid in water
Hydrolysis; 4 h; Heating;
参考文献
Kim, Dae Young; Lee, Yong Mi; Choi, Young Jae
Tetrahedron, 1999 , vol. 55, # 45 p. 12983 - 12990
反应条件
1: 65 percent / activated zinc dust / tetrahydrofuran / 0.17 h / Heating
2: 82 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
Linderman, Russell J.; Graves, David M.
Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 661 - 668
反应条件
hydrogenchloride; sodium hydroxide
1.) 1 h, r.t., H2O; Yield given. Multistep reaction;
参考文献
Ishikawa, Nobuo; Takaoka, Akio; Iwakiri, Hiroshi; Kubota, Satoshi; Kagaruki, S. R. F.
Chemistry Letters, 1980 , p. 1107 - 1110
反应条件
diethyl ether; sodium hydride
参考文献
Bergmann et al.
Journal of the Chemical Society, 1959 , p. 3278,3282
反应条件
sodium methylate; Petroleum ether
参考文献
Bergmann et al.
Journal of the Chemical Society, 1959 , p. 3278,3282
反应条件
Yield given. Multistep reaction;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 273 - 277
参考文献
Bergmann et al.
Journal of the Chemical Society, 1959 , p. 3278,3282
反应条件
1: 44 percent / sodium borohydride / ethanol / 5 h / -78 - 20 °C
2: DIBAL / tetrahydrofuran; toluene / 20 °C
3: 48 percent / pyridine / 24 h / 20 °C
View Scheme
参考文献
Engman, Mattias; Diesen, Jarle S.; Paptchikhine, Alexander; Andersson, Pher G.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4536 - 4537
