1: 1) KOH / 1) THF, MeOH, reflux, 5 h, 2) r.t., 2 h 2: 1) Ti(i-PrO)4, (+)-diethyltartrate, 2) t-butylhydroperoxide / 1) 1,2-dichloroethane, r.t., 10 min, 2) -20 deg C, 16 h 3: 1) I2, PPh3, 2) NaI / 1) CH3CN, r.t., 5 min, 2) reflux, 1 h 4: 11 percent / NaSMe / hexamethylphosphoric acid triamide / 3 h / 100 °C View Scheme