2-(氯甲基)-6-苯基吡啶合成路线 （共 5 条）
反应条件
thionyl chloride T=20°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1228067 B1, 2004 ;
Location in patent: Page 60 ;
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 90 °C 2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h 3.1: acetic anhydride / 12 h / 90 °C 3.2: 0 - 20 °C 4.1: thionyl chloride / dichloromethane / 0 - 20 °C View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h 2.1: acetic anhydride / 12 h / 90 °C 2.2: 0 - 20 °C 3.1: thionyl chloride / dichloromethane / 0 - 20 °C View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
反应条件
1.1: acetic anhydride / 12 h / 90 °C 1.2: 0 - 20 °C 2.1: thionyl chloride / dichloromethane / 0 - 20 °C View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 90 °C 2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h 3.1: acetic anhydride / 12 h / 90 °C 3.2: 0 - 20 °C 4.1: thionyl chloride / dichloromethane / 0 - 20 °C View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
