4-(2-羟基乙基)-2,2-二甲基噁唑啉-3-羧酸-(S)-叔丁酯合成路线 （共 17 条）
参考文献
Ma, Dawei; Zhu, Wei
Synlett, 2006 , # 8 p. 1181 - 1184
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Ollivier, Anthony; Goubert, Marlene; Tursun, Ahmatjan; Canet, Isabelle; Sinibaldia, Marie-Eve
Arkivoc, 2010 , vol. 2010, # 9 p. 108 - 126
反应条件
silica gel in dichloromethane; water T=20°C; 72 h;
参考文献
Organic Letters, , vol. 7, # 7 p. 1423 - 1426
反应条件
water; silica gel in dichloromethane T=20°C; 96 h; Product distribution / selectivity;
参考文献
WO2006/94770 A2, ;
Page/Page column 14 ;
反应条件
hydrogenchloride; lithium borohydride; sodium chloride; potassium hydrogencarbonate in tetrahydrofuran; methanol; water
参考文献
EP520336 A2, ;
EP 0520336 A2
反应条件
toluene-4-sulfonic acid T=25°C; 36 h;
参考文献
Hou, Duen-Ren; Burgess, Kevin
Organic Letters, 1999 , vol. 1, # 11 p. 1745 - 1747
反应条件
1: triethylamine / dioxane; H2O / 25 °C 2: 73 percent / NaBH4 / ethanol / 25 °C 3: 48 percent / TsOH / CH2Cl2 View Scheme
参考文献
Organic Letters, , vol. 1, # 11 p. 1745 - 1747
反应条件
1: 73 percent / NaBH4 / ethanol / 25 °C 2: 48 percent / TsOH / CH2Cl2 View Scheme
参考文献
Organic Letters, , vol. 1, # 11 p. 1745 - 1747
反应条件
toluene-4-sulfonic acid in dichloromethane T=20°C; 36 h; Product distribution / selectivity;
参考文献
WO2006/94770 A2, ;
Page/Page column 3; 13 ;
反应条件
1.1: p-toluenesulfonic acid monohydrate / CH2Cl2 / 2 h / 20 °C 1.2: 67 h / 20 °C 2.1: 14.64 g / silica gel / CH2Cl2; H2O / 72 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 7 p. 1423 - 1426
