5-氟-2-甲基嘧啶-4(3H)-酮合成路线 (共 3 条)
反应条件
1: ethyl (R)-(+)-2-fluoroacetate; formic acid ethyl ester With sodium hydride in tetrahydrofuran T=0 - 20°C; 72 h; 2: 1-Imino-ethanamine hydrochloride With sodium ethanolate in ethanol Heating / reflux;
参考文献
PFIZER INC.
Patent: WO2006/72831 A1, 2006 ;
Location in patent: Page/Page column 66 ;
WO 2006/072831 A1
反应条件
1: ethyl (R)-(+)-2-fluoroacetate; formic acid ethyl ester With sodium hydride in tetrahydrofuran T=0 - 20°C; 72 h; 2: 1-Imino-ethanamine hydrochloride With sodium ethanolate in ethanol Heating / reflux; 3: With hydrogenchloride in water pH=6;
参考文献
PFIZER INC.
Patent: WO2008/96260 A1, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/096260 A1
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=110°C; 1.5 h;
参考文献
PFIZER INC.
Patent: WO2008/96260 A1, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/096260 A1