1: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 4 h / Ambient temperature 2: 69 percent / sodium methoxide / methanol / 0.5 h / -35 °C 3: 87 percent / diisopropylethylamine / 4.5 h 4: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 86 percent / dimethylformamide / 3.75 h / 65 °C 2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 4 h / Ambient temperature 3: 69 percent / sodium methoxide / methanol / 0.5 h / -35 °C 4: 87 percent / diisopropylethylamine / 4.5 h 5: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 87 percent / diisopropylethylamine / 4.5 h 2: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 69 percent / sodium methoxide / methanol / 0.5 h / -35 °C 2: 87 percent / diisopropylethylamine / 4.5 h 3: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 32.48 g / triethylamine / methanol / 0.33 h 2: 98 percent / triethylamine / CH2Cl2 / 0.25 h / -30 °C 3: 1) sodium hydride / 1) DMF, room temperature, 1 h, 2) 60 deg C, 30 min 4: 68 percent / LiBH4 / tetrahydrofuran / 0.5 h / 60 °C 5: 87.4 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 6: 78.1 percent / dimethylformamide / 1 h / 100 °C 7: 78 percent / H2NNH2*H2O / CH2Cl2; methanol / 5 h / 60 °C 8: 41 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 9: 1) AgNO3, pyridine, 2) H2S / 1) MeOH, CH2Cl2, H2O, room temperature, 10 min 10: diisopropylethylamine / acetonitrile / 4.5 h 11: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 98 percent / triethylamine / CH2Cl2 / 0.25 h / -30 °C 2: 1) sodium hydride / 1) DMF, room temperature, 1 h, 2) 60 deg C, 30 min 3: 68 percent / LiBH4 / tetrahydrofuran / 0.5 h / 60 °C 4: 87.4 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 5: 78.1 percent / dimethylformamide / 1 h / 100 °C 6: 78 percent / H2NNH2*H2O / CH2Cl2; methanol / 5 h / 60 °C 7: 41 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 8: 1) AgNO3, pyridine, 2) H2S / 1) MeOH, CH2Cl2, H2O, room temperature, 10 min 9: diisopropylethylamine / acetonitrile / 4.5 h 10: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 1) sodium hydride / 1) DMF, room temperature, 1 h, 2) 60 deg C, 30 min 2: 68 percent / LiBH4 / tetrahydrofuran / 0.5 h / 60 °C 3: 87.4 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 4: 78.1 percent / dimethylformamide / 1 h / 100 °C 5: 78 percent / H2NNH2*H2O / CH2Cl2; methanol / 5 h / 60 °C 6: 41 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 7: 1) AgNO3, pyridine, 2) H2S / 1) MeOH, CH2Cl2, H2O, room temperature, 10 min 8: diisopropylethylamine / acetonitrile / 4.5 h 9: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 87.4 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 2: 78.1 percent / dimethylformamide / 1 h / 100 °C 3: 78 percent / H2NNH2*H2O / CH2Cl2; methanol / 5 h / 60 °C 4: 41 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 5: 1) AgNO3, pyridine, 2) H2S / 1) MeOH, CH2Cl2, H2O, room temperature, 10 min 6: diisopropylethylamine / acetonitrile / 4.5 h 7: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 41 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 2: 1) AgNO3, pyridine, 2) H2S / 1) MeOH, CH2Cl2, H2O, room temperature, 10 min 3: diisopropylethylamine / acetonitrile / 4.5 h 4: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme

1: 68 percent / LiBH4 / tetrahydrofuran / 0.5 h / 60 °C 2: 87.4 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 3: 78.1 percent / dimethylformamide / 1 h / 100 °C 4: 78 percent / H2NNH2*H2O / CH2Cl2; methanol / 5 h / 60 °C 5: 41 percent / triethylamine / CH2Cl2 / 0.33 h / -30 °C 6: 1) AgNO3, pyridine, 2) H2S / 1) MeOH, CH2Cl2, H2O, room temperature, 10 min 7: diisopropylethylamine / acetonitrile / 4.5 h 8: 72 percent / AlCl3, anisole / CH2Cl2 / 1.5 h / -30 °C View Scheme